Phenylbutyric acid, (R)-(-)-2-
(R)-(-)-2-Phenylbutyric acid
CAS: 938-79-4
Molecular Formula: C10H12O2
Phenylbutyric acid, (R)-(-)-2- - Names and Identifiers
| Name | (R)-(-)-2-Phenylbutyric acid |
| Synonyms | (2R)-2-Phenylbutyric acid (R)-2-Phenylbutanoic acid (2R)-2-Phenylbutanoic acid (R)-(-)-2-PHENYLBUTYRIC ACID (R)-(-)-2-Phenylbutyric acid (αR)-α-Ethylbenzeneacetic acid Phenylbutyric acid, (R)-(-)-2- (r)-(-)-à-ethylphenylacetic acid (R)-(-)-alpha-Ethylphenylaceticacid benzeneacetic acid, alpha-ethyl-, (alphaR)- |
| CAS | 938-79-4 |
| InChI | InChI=1/C10H12O2/c1-2-9(10(11)12)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,11,12)/t9-/m1/s1 |
Phenylbutyric acid, (R)-(-)-2- - Physico-chemical Properties
| Molecular Formula | C10H12O2 |
| Molar Mass | 164.2 |
| Density | 1.055 g/mL at 25 °C (lit.) |
| Boling Point | 102-104 °C/0.4 mmHg (lit.) |
| Specific Rotation(α) | [α]D20 -92～-98゜ (c=4, C6H5CH3) |
| Flash Point | >230°F |
| Solubility | Chloroform (Slightly), Ethanol (Slightly), Toluene (Slightly) |
| Vapor Presure | 0.00288mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 2327346 |
| Storage Condition | Refrigerator |
| Refractive Index | n20/D 1.516 |
| MDL | MFCD00063165 |
Phenylbutyric acid, (R)-(-)-2- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S23 - Do not breathe vapour. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29163900 |
Phenylbutyric acid, (R)-(-)-2- - Introduction
(R)-(-)-2-Phenylbutyric acid is an organic compound with the chemical formula C10H12O2. It had the appearance of a white crystalline solid.
Nature:
- (R)-(-)-2-Phenylbutyric acid has a specific three-dimensional structure, it is an optically active substance, and the optical rotation is negative.
-Its melting point is about 55-57 degrees Celsius.
- (R)-(-)-2-Phenylbutyric acid has low solubility, slightly soluble in water at room temperature, and better solubility in organic solvents.
Use:
- (R)-(-)-2-Phenylbutyric acid is an important chiral synthetic intermediate, which can be used in the synthesis of drugs, spices and pesticides.
-It can also be used as a detaching agent and oxidizing agent.
Method:
(R)-(-)-2-Phenylbutyric acid is usually obtained by a two-step synthesis. First, (R)-(-)-2-phenylbutanone was synthesized by an asymmetric nucleophilic addition reaction using a titanium group metal catalyst of 1-phenylacetone and triethylamine. Next, (R)-(-)-2-phenylbutanone is subjected to an acidic hydrolysis reaction to obtain (R)-(-)-2-Phenylbutyric acid.
Safety Information:
Compounds with phenyl groups may have certain toxicity, so the relevant safety procedures should be followed when using and storing (R)-(-)-2-Phenylbutyric acid.
Nature:
- (R)-(-)-2-Phenylbutyric acid has a specific three-dimensional structure, it is an optically active substance, and the optical rotation is negative.
-Its melting point is about 55-57 degrees Celsius.
- (R)-(-)-2-Phenylbutyric acid has low solubility, slightly soluble in water at room temperature, and better solubility in organic solvents.
Use:
- (R)-(-)-2-Phenylbutyric acid is an important chiral synthetic intermediate, which can be used in the synthesis of drugs, spices and pesticides.
-It can also be used as a detaching agent and oxidizing agent.
Method:
(R)-(-)-2-Phenylbutyric acid is usually obtained by a two-step synthesis. First, (R)-(-)-2-phenylbutanone was synthesized by an asymmetric nucleophilic addition reaction using a titanium group metal catalyst of 1-phenylacetone and triethylamine. Next, (R)-(-)-2-phenylbutanone is subjected to an acidic hydrolysis reaction to obtain (R)-(-)-2-Phenylbutyric acid.
Safety Information:
Compounds with phenyl groups may have certain toxicity, so the relevant safety procedures should be followed when using and storing (R)-(-)-2-Phenylbutyric acid.
Last Update：2024-04-09 21:01:54
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